Shortage of anesthetics: Think of inhaled sedation!
نویسندگان
چکیده
منابع مشابه
Inhaled anesthetics: an historical overview.
Inhalational agents have played a pivotal role in anesthesia history. The first publicly demonstrated anesthetic of the modern era, diethyl ether, was an inhalational anesthetic. The attributes of a good agent, ability to rapidly induce anesthesia, with limited side effects has led research efforts for over a hundred and fifty years. The explosion hazard was largely conquered with the developme...
متن کاملMolecular interactions between inhaled anesthetics and proteins.
The fundamental interactions of inhalational anesthetics with proteins have been considered in some detail, using specific examples where appropriate to illustrate these interactions and demonstrate progress. It is now clear that these low-affinity volatile molecules with rapid kinetics can specifically bind to discrete sites in some proteins at reasonable pharmacological concentrations, and so...
متن کاملG protein-coupled receptors as direct targets of inhaled anesthetics.
The molecular pharmacology of inhalational anesthetics remains poorly understood. Despite accumulating evidence suggesting that neuronal membrane proteins are potential targets of inhaled anesthetics, most currently favored membrane protein targets lack any direct evidence for anesthetic binding. We report herein the location of the binding site for the inhaled anesthetic halothane at the amino...
متن کاملInhaled Anesthetics Promote Albumin Dimerization through Reciprocal Exchange of Subdomains
Inhaled anesthetics affect protein-protein interaction, but the mechanisms underlying these effects are still poorly understood. We examined the impact of sevoflurane and isoflurane on the dimerization of human serum albumin (HSA), a protein with anesthetic binding sites that are well characterized. Intrinsic fluorescence emission was analyzed for spectral shifting and self-quenching, and contr...
متن کاملGlobal warming potential of inhaled anesthetics: application to clinical use.
BACKGROUND Inhaled anesthetics are recognized greenhouse gases. Calculating their relative impact during common clinical usage will allow comparison to each other and to carbon dioxide emissions in general. METHODS We determined infrared absorption cross-sections for sevoflurane and isoflurane. Twenty-year global warming potential (GWP(20)) values for desflurane, sevoflurane, and isoflurane w...
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ژورنال
عنوان ژورنال: Journal of Critical Care
سال: 2021
ISSN: 0883-9441
DOI: 10.1016/j.jcrc.2020.09.009